Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors
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چکیده
منابع مشابه
Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors.
Neuroinflammation mediated by microglia cells plays a critical role in the development of Alzheimer's disease. To identify novel natural neuroinflammation inhibitors, a bioactivity-guided phytochemical research was performed on the traditional Chinese medicine "Awei", that exhibited a significant inhibitory effect on nitric oxide production in over-activated microglia cells. The research identi...
متن کاملAnti-Viral Evaluation of Sesquiterpene Coumarins from Ferula assa-foetida against HSV-1
Several complications attributed with Herpes virus related infections and the emergence of drug resistant viruses prompt scientists to search for new drugs. Several terpenoids and coumarins have shown anti HSV effects while no sesquiterpene coumarins have been previously tested for HSV treatment. Three sesquiterpene coumarins badrakemin acetate (1), kellerin (2) and samarcandin diastereomer (3)...
متن کاملAntiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate.
The exudate of Ferula narthex Boiss. (Apiaceae) is widely used in the Indian subcontinent as a spice and because of its health effects. Six sesquiterpene coumarins have been isolated from this exudate: feselol, ligupersin A, asacoumarin A, 8'-O-acetyl-asacoumarin A, 10'R-karatavacinol and 10'R-acetyl-karatavacinol. Based on its use in infectious and diabetic conditions, the isolated constituent...
متن کاملCorrigendum: Bioassay-Guided Isolation of Sesquiterpene Coumarins from Ferula narthex Bioss: A New Anticancer Agent
[This corrects the article on p. 26 in vol. 7, PMID: 26909039.].
متن کاملSesquiterpene coumarins from Ferula fukanensis and their pro-inflammatory cytokine gene expression inhibitory effects.
Six new sesquiterpene coumarin derivatives, fukanefuromarin H-M (1-6), were isolated from an 80% aqueous methanol extract of the roots of Ferula fukanensis. The structures were elucidated on the basis of spectroscopic evidence, particularly heteronuclear multiple-bond connectivity (HMBC) and high-resolution MS. The sesquiterpene coumarin derivatives inhibited nitric oxide (NO) and inducible NO ...
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ژورنال
عنوان ژورنال: Planta Medica
سال: 2016
ISSN: 0032-0943,1439-0221
DOI: 10.1055/s-0042-109271